In coaching disabled martial artists, I've had a varied and diverse experience.
I've always done blindfold chi sao in my Wing Chun, but doing it with a blind student took the whole thing to a new dimension. The same applies for blindfold grappling.
When training with my friend in the wheelchair I used to sit in a chair and train pads and sticks with him. And as for applying the techniques against a standing attacker, it gave me another new appreciation of this dimension of combat.
There have also been various students with missing limbs, including one guy who was missing an arm (yes he did all the jokes about "Unarmed Combat") who became an expert kicker. And as his right elbow was just an elbow he became lethal with it.
This can be a rewarding teaching experience as well as a great learning experience.